Background and Aim: In civil law, based on Imami jurisprudence, particularly the rule of "Divorce is in the hands of the one who marriages" the authority to divorce is entrusted to the husband as the first rule. However, as marriage is a contract that creates material and legal effects between the couple, consequently, there are a series of duties and rights based on the principle of justice between the couple, so the wife’, s right to divorce can be granted in certain conditions,one of the predictable positions would be cases in which the wife suffers from excessive medical impairments. Now the authors' question is that considering the focus of jurisprudence and law on legal cases under the rule of "no hardship" (La Haraj), are there any emerging medical predicaments based on which the right to divorce can be delegated to the wife? Materials and Methods: This research has been written by a descriptiveanalytical method and it has been tried to study some emerging examples of painful therapeutic incidences which grant the wife’, s right to divorce according to the focus of jurisprudence and law on traditional examples under the rule of "no hardship". Findings: Although in the early legislative system or jurisprudential writings, the primary focus on granting the wife’, s right to divorce was narrowed to a series of classic examples, by analyzing the original jurisprudential sources and isolating the adequate causes, it was found that in some cases in which the wife suffers from physical, sexual or Spiritual difficulties in the family, based on the criteria of jurisprudence and law, mainly based on the application of the rule of hardness and embarrassment, acquiescing the wife’, s right to divorce is considered permissible and inevitable.